Is MOTS-c from Pure North Peptides HPLC verified?

Yes. Every MOTS-c lot Pure North Peptides ships is HPLC-purity tested at synthesis and retested by Janoshik Analytical before release. The lot-specific Certificate of Analysis is published on the Lab Results page.

How is MOTS-c shipped?

MOTS-c is lyophilized at synthesis, sealed under nitrogen, and shipped across Canada via Canada Post Xpresspost in ~4 days. Free shipping over $250 CAD. ~4 days transit Canada-wide.

Where can I see the COA for MOTS-c?

Lot-specific Certificate of Analysis available on request — email purenorthpeptides@proton.me with the lot/batch number from your order confirmation and we'll send it for your records.

What does HPLC-verified mean?

Every lot we sell is tested by an independent third-party lab (Janoshik Analytical) using High-Performance Liquid Chromatography. The Certificate of Analysis reports purity, peptide content by mass, and identity. We post the COA next to each product so you can verify before ordering.

How is it shipped within Canada?

Canada Post Xpresspost. Most provinces arrive in ~4 days from dispatch. Free shipping on Canadian orders over $250; otherwise a flat $25 shipping fee applies.

Is this for human or animal use?

All Pure North products are supplied strictly for laboratory research use only — in-vitro reference standards. By ordering you confirm you have read and accept our Research Use Declaration.

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Home / Catalog / Longevity / MOTS-c 40 mg

Longevity · Mitochondrial-derived peptide

MOTS-c 40 mg

SKU LUM-MOTSC-10 · C₁₀₀H₁₅₈N₂₆O₂₂S · 2174.55 g/mol · CAS 1627580-64-6

A 16-residue mitochondrial-derived peptide encoded within the 12S rRNA gene. Studied for AMPK activation and metabolic homeostasis.

Purity (HPLC): ≥ 99.16%
Net peptide: 5.00 mg ± 2%
Endotoxin: < 0.5 EU/mg
Format: Lyophilized vial
Storage: −20 °C, desiccated
Shelf life: 24 months from MFG

$80CAD / 40 mg vial

In stock · Lot LM-2774

Add $250 for Free shipping

Third-party COA on fileCocer lab · HPLC ≥ 99% · Janoshik verified — view report →

HPLC + MS verified per lot
~4 days to your door
COA bundled with shipment
Lot samples retained 5 years

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Overview

MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a 16-residue peptide encoded within the mitochondrial genome and translated in the cytoplasm. It activates AMPK, modulates folate–methionine cycling, and is investigated for its roles in glucose homeostasis, exercise capacity, and longevity pathways.

Each vial is lyophilized from acetate buffer, sealed under nitrogen, and shipped ~4 days from our lab.

Research applications

AMPK-activation screens (Thr172 phosphorylation), 5-methyl-THF/SAM metabolomics, in-vitro glucose-uptake assays in skeletal myoblasts, and comparative mitochondrial-derived peptide pharmacology.

Sold for laboratory research only. This material is not a drug, food, or cosmetic and is not intended for diagnostic, therapeutic, or recreational use.

Identity

Parameter	Value
Sequence	MRWQEMGYIFYPRKLR
Molecular formula	C₁₀₀H₁₅₈N₂₆O₂₂S
Molecular weight	2174.55 g/mol
CAS number	1627580-64-6
Length	16 residues

Quality

Test	Specification
HPLC purity	99.443%
Mass confirmation	ESI-MS within 0.5 Da
Net peptide content	≥ 80% by AAA
Endotoxin	< 0.5 EU/mg (LAL)
Bioburden	< 10 CFU/g
Residual TFA	< 1.0%

Lot LM-2774

Manufactured 04 Mar 2026 · Released 11 Mar 2026 · Tested by Pure North QC, Canada. Retain samples held under storage spec for five years from release date.

Verification

Method	Result
RP-HPLC at 220 nm	99.13% main peak
ESI-MS (positive)	2174.6 Da (theor. 2174.55)
Amino acid analysis	82.1% net peptide
LAL endotoxin	< 0.05 EU/mg
Karl Fischer (water)	2.8% w/w

Reconstitution

Allow vial to reach room temperature before opening (≥ 20 minutes). Reconstitute with 1.0–2.5 mL of sterile bacteriostatic water (0.9% benzyl alcohol). Inject solvent slowly down the inner wall of the vial; do not direct stream onto the lyophilized cake.

Swirl gently for 30 seconds. Do not vortex. Allow to dissolve for 5 minutes; clarity should be complete with no visible particulates.

Storage after reconstitution

Reconstituted solution is stable for 28 days at 2–8 °C in original vial. For longer storage, aliquot into low-binding tubes and hold at −80 °C; avoid repeated freeze-thaw cycles. Discard if turbidity, color change, or particulate matter is observed.

Selected references

Lee C et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis. Cell Metab. 2015;21(3):443–454.

Reynolds JC et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021;12(1):470.

Kim KH et al. The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression. Cell Metab. 2018;28(3):516–524.

Citing this material

MOTS-c reference standard, ≥99% (HPLC), Pure North Peptides Inc., Cat. No. LUM-MOTSC-10, Lot LM-2774.

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